Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors

J Med Chem. 1994 Sep 30;37(20):3200-4. doi: 10.1021/jm00046a002.
No abstract available

MeSH terms

  • 4-Hydroxycoumarins / chemistry*
  • 4-Hydroxycoumarins / metabolism
  • 4-Hydroxycoumarins / pharmacology
  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Binding, Competitive
  • Biological Availability
  • Crystallization
  • Dogs
  • Drug Design*
  • HIV Protease / metabolism
  • HIV Protease Inhibitors / chemistry*
  • HIV-1 / drug effects
  • HIV-1 / enzymology
  • Hydrogen Bonding
  • Models, Molecular
  • Molecular Sequence Data
  • Pyrones / chemical synthesis*
  • Pyrones / chemistry*
  • Pyrones / metabolism
  • Pyrones / pharmacokinetics
  • Pyrones / pharmacology
  • Rats

Substances

  • 4-Hydroxycoumarins
  • HIV Protease Inhibitors
  • Pyrones
  • U 96988
  • HIV Protease